abstract：BACKGROUND:The focus on noncancer causes of death in patients with breast cancer (BC) remains superficial. The objective of the current study was to assess and quantify causes of death after BC diagnosis. METHODS:In total, 754,270 women with BC in the United States who were diagnosed during 2000 through 2015 and retri...

journal_title：Cancer

authors： Afifi AM,Saad AM,Al-Husseini MJ,Elmehrath AO,Northfelt DW,Sonbol MB

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Outcomes for patients with relapsed/refractory acute myeloid leukemia (R/R AML) remain poor. Novel therapies specifically targeting AML are of high interest. Brentuximab vedotin (BV) is an antibody-drug conjugate that is specific for human CD30. In this phase 1 dose escalation study, the authors evaluated th...

journal_title：Cancer

authors： Narayan R,Blonquist TM,Emadi A,Hasserjian RP,Burke M,Lescinskas C,Neuberg DS,Brunner AM,Hobbs G,Hock H,McAfee SL,Chen YB,Attar E,Graubert TA,Bertoli C,Moran JA,Bergeron MK,Foster JE,Ramos AY,Som TT,Vartanian MK,

更新日期：2020-03-15 00:00:00

abstract：BACKGROUND:Immune checkpoint inhibitors (ICIs) represent an appealing treatment for patients with advanced urothelial cancer (aUC) and a poor performance status (PS). However, the benefit of ICIs for patients with a poor PS remains unknown. It was hypothesized that a poor Eastern Cooperative Oncology Group (ECOG) PS (≥...

journal_title：Cancer

authors： Khaki AR,Li A,Diamantopoulos LN,Bilen MA,Santos V,Esther J,Morales-Barrera R,Devitt M,Nelson A,Hoimes CJ,Shreck E,Assi H,Gartrell BA,Sankin A,Rodriguez-Vida A,Lythgoe M,Pinato DJ,Drakaki A,Joshi M,Isaacsson Velho P

更新日期：2020-03-15 00:00:00

abstract：BACKGROUND:The objective of this study was to characterize chronic disease, health-related quality of life (HRQOL), emotional distress, and social attainment among long-term survivors of neuroblastoma. METHODS:Chronic health conditions among 136 ≥10-year neuroblastoma survivors (median age, 31.9 years; range, 20.2-54....

journal_title：Cancer

authors： Wilson CL,Brinkman TM,Cook C,Huang S,Hyun G,Green DM,Furman WL,Bhakta N,Ehrhardt MJ,Krasin MJ,Robison LL,Ness KK,Hudson MM

更新日期：2020-03-15 00:00:00

abstract：:Transcriptional dysregulation induced by disease-defining genetic alterations of proteins in transcriptional machinery is a key feature of cancers. Mediator complex subunit 12 (MED12) is the central architectural subunit in the kinase module of Mediator, a large transcriptional regulatory complex that controls essenti...

journal_title：Cancer

authors： Zhang S,O'Regan R,Xu W

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Screening colonoscopy (SC) for colorectal cancer (CRC) is underused by Latino individuals. The current randomized clinical trial examined the impact of 3 interventions: 1) patient navigation; 2) patient navigation plus standard Centers for Disease Control and Prevention print materials; and 3) patient naviga...

journal_title：Cancer

authors： DuHamel KN,Schofield EA,Villagra C,Sriphanlop P,Itzkowitz SH,Cotter G,Cohen N,Erwin DO,Winkel G,Thompson HS,Zauber AG,Jandorf LH

更新日期：2020-02-15 00:00:00

abstract：BACKGROUND:Carfilzomib improves survival in patients with recurrent myeloma. Given the strict eligibility criteria in clinical trials, the actual frequency of cardiac adverse events (CAEs) and pulmonary adverse events (PAEs) and the risk factors associated with these AEs in the general population need to be established...

journal_title：Cancer

authors： Fakhri B,Fiala MA,Shah N,Vij R,Wildes TM

更新日期：2020-02-15 00:00:00

abstract：BACKGROUND:Greater than one-half of children who are treated for acute lymphoblastic leukemia (ALL) develop ≥1 treatment-related medical conditions in their lifetime, many of which are known risk factors for diabetes mellitus. In the current study, the authors evaluated the prevalence and risk factors of diabetes melli...

journal_title：Cancer

authors： Williams HE,Howell CR,Chemaitilly W,Wilson CL,Karol SE,Nolan VG,Smeltzer MP,Green DM,Ehrhardt MJ,Mulrooney DA,Pui CH,Hudson MM,Robison LL,Ness KK

更新日期：2020-02-15 00:00:00

abstract：BACKGROUND:Optimal chemotherapy for treating mixed-phenotype acute leukemia (MPAL) and the role of hematopoietic stem cell transplantation (HSCT) remain uncertain. Major limitations in interpreting available data are MPAL's rarity and the use of definitions other than the currently widely accepted criteria: the World H...

journal_title：Cancer

authors： Orgel E,Alexander TB,Wood BL,Kahwash SB,Devidas M,Dai Y,Alonzo TA,Mullighan CG,Inaba H,Hunger SP,Raetz EA,Gamis AS,Rabin KR,Carroll AJ 3rd,Heerema NA,Berman JN,Woods WG,Loh ML,Zweidler-McKay PA,Horan JT,Children's

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Active surveillance (AS) is an accepted means of managing low-risk prostate cancer. Because of the rarity of downstream events, data from existing AS cohorts cannot yet address how differences in surveillance intensity affect metastasis and mortality. This study projected the comparative benefits of differen...

journal_title：Cancer

authors： Lange JM,Laviana AA,Penson DF,Lin DW,Bill-Axelson A,Carlsson SV,Newcomb LF,Trock BJ,Carter HB,Carroll PR,Cooperberg MR,Cowan JE,Klotz LH,Etzioni RB

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Sixty percent of patients with stage IV melanoma may develop brain metastases, which result in significantly increased morbidity and a poor overall prognosis. Phase 3 studies of melanoma usually exclude patients with untreated brain metastases; therefore, clinical data for intracranial responses to treatment...

journal_title：Cancer

authors： Holbrook K,Lutzky J,Davies MA,Davis JM,Glitza IC,Amaria RN,Diab A,Patel SP,Amin A,Tawbi H

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Health insurance is a key mediator of health care disparities. Outcomes in bladder cancer, one of the costliest diseases to treat, may be especially sensitive to a patient's insurance status. METHODS:The Surveillance, Epidemiology, and End Results registry and the National Cancer Data Base were used to iden...

journal_title：Cancer

authors： Fletcher SA,Cole AP,Lu C,Marchese M,Krimphove MJ,Friedlander DF,Mossanen M,Kilbridge KL,Kibel AS,Trinh QD

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Survivors of childhood leukemia/lymphoma are at increased risk for reduced bone mineral density (BMD). The authors sought to determine the frequency of reduced BMD detected by off-therapy surveillance, factors associated with reduced BMD, and the association of reduced BMD with fractures. METHODS:This cross...

journal_title：Cancer

authors： Bloomhardt HM,Sint K,Ross WL,Rotatori J,Ness K,Robinson C,Carpenter TO,Chow EJ,Kadan-Lottick NS

更新日期：2020-01-01 00:00:00

abstract：:The majority of patients with advanced ovarian cancer progress after first-line therapy and require further treatment. Tumor biology, prior chemotherapy, responses to previous therapy, performance status, and toxicity are the characteristics that influence treatment choice. These criteria have been linked to the time ...

journal_title：Cancer

authors： Pignata S,Pisano C,Di Napoli M,Cecere SC,Tambaro R,Attademo L

更新日期：2019-12-15 00:00:00

abstract：BACKGROUND:Discrimination and trust are known barriers to accessing health care. Despite well-documented racial disparities in the ovarian cancer care continuum, the role of these barriers has not been examined. This study evaluated the association of everyday discrimination and trust in physicians with a prolonged int...

journal_title：Cancer

authors： Mullins MA,Peres LC,Alberg AJ,Bandera EV,Barnholtz-Sloan JS,Bondy ML,Funkhouser E,Moorman PG,Peters ES,Terry PD,Schwartz AG,Lawson AB,Schildkraut JM,Cote ML

更新日期：2019-12-15 00:00:00

abstract：BACKGROUND:There is a need for guidelines on patient navigation activities to promote both the quality of patient navigation and the standards of reimbursement for these services because a lack of reimbursement is a major barrier to the implementation, maintenance, and sustainability of these programs. METHODS:A broad...

journal_title：Cancer

authors： Freund KM,Haas JS,Lemon SC,Burns White K,Casanova N,Dominici LS,Erban JK,Freedman RA,James TA,Ko NY,LeClair AM,Moy B,Parsons SK,Battaglia TA

更新日期：2019-12-15 00:00:00

abstract：BACKGROUND:Patients with non-Hodgkin lymphoma (NHL) have an increased risk of venous thromboembolism (VTE), particularly when they are receiving treatment. Blood or marrow transplantation (BMT) is recommended for relapsed/refractory NHL, and the risk of VTE after these patients undergo BMT is uncertain. METHODS:Patien...

journal_title：Cancer

authors： Gangaraju R,Chen Y,Hageman L,Wu J,Francisco L,Kung M,Ness E,Parman M,Weisdorf DJ,Forman SJ,Arora M,Armenian SH,Bhatia S

更新日期：2019-12-15 00:00:00

abstract：BACKGROUND:Fear of cancer recurrence (FCR) adversely affects quality of life. Cigarette smoking increases the risk of recurrence and may exacerbate FCR among survivors who smoke. FCR also may motivate quitting, but research on whether quitting reduces long-term survivors' FCR is lacking. Among long-term survivors of va...

journal_title：Cancer

authors： Westmaas JL,Thewes B,Séguin Leclair C,Lebel S

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Diabetes is positively associated with various cancers, but its relationship with tumors of the esophagus/esophagogastric junction remains unclear. METHODS:Data were harmonized across 13 studies in the International Barrett's and Esophageal Adenocarcinoma Consortium, comprising 2309 esophageal adenocarcinom...

journal_title：Cancer

authors： Petrick JL,Li N,Anderson LA,Bernstein L,Corley DA,El Serag HB,Hardikar S,Liao LM,Liu G,Murray LJ,Rubenstein JH,Schneider JL,Shaheen NJ,Thrift AP,van den Brandt PA,Vaughan TL,Whiteman DC,Wu AH,Zhao WK,Gammon MD,Coo

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:In the phase 3 MARIANNE trial, trastuzumab emtansine (T-DM1) with or without pertuzumab showed noninferior progression-free survival and better tolerability than trastuzumab plus a taxane (HT) for the first-line treatment of human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer. Thi...

journal_title：Cancer

authors： Perez EA,Barrios C,Eiermann W,Toi M,Im YH,Conte P,Martin M,Pienkowski T,Pivot XB,Burris HA 3rd,Petersen JA,De Haas S,Hoersch S,Patre M,Ellis PA

更新日期：2019-11-15 00:00:00

abstract：:Because chronic lymphocytic leukemia is a heterogeneous disease, there are considerable efforts underway to develop increasingly accurate and precise analytics with which to estimate the probability of future events such as the need for and probability of response to therapy, progression-free survival, and survival. T...

journal_title：Cancer

authors： Montserrat E,Gale RP

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Despite an increased risk of subsequent human papillomavirus (HPV)-related malignancies, HPV vaccine initiation rates among cancer survivors remain critically low. The purpose of this study was to determine the relationship between HPV vaccine intent and subsequent vaccine initiation among cancer survivors b...

journal_title：Cancer

authors： Cherven B,Castellino SM,Chen Y,Wong FL,York JM,Wasilewski-Masker K,Hudson MM,Bhatia S,Klosky JL,Landier W

更新日期：2019-11-01 00:00:00

abstract：:The acquisition of ligand-independent ESR1 mutations during aromatase inhibitor therapy in metastatic estrogen receptor (ER)-positive breast cancer is a common mechanism of hormonal therapy resistance. Preclinical and clinical studies have demonstrated that ESR1 mutations can preexist in primary tumors and can be enri...

journal_title：Cancer

authors： Dustin D,Gu G,Fuqua SAW

更新日期：2019-11-01 00:00:00

abstract：:Patients who are diagnosed with osteosarcoma (OS) today receive the same therapy that patients have received over the last 4 decades. Extensive efforts to identify more effective or less toxic regimens have proved disappointing. As we enter a postgenomic era in which we now recognize OS not as a cancer of mutations bu...

journal_title：Cancer

authors： Roberts RD,Lizardo MM,Reed DR,Hingorani P,Glover J,Allen-Rhoades W,Fan T,Khanna C,Sweet-Cordero EA,Cash T,Bishop MW,Hegde M,Sertil AR,Koelsche C,Mirabello L,Malkin D,Sorensen PH,Meltzer PS,Janeway KA,Gorlick R,Cro

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:There exist insufficient data characterizing patients with multiple myeloma (MM) who experienced prolonged survival. A population-based analysis of long-term survivors was conducted to investigate the roles of sociodemographic factors and upfront stem cell transplantation (SCT). METHODS:The National Cancer ...

journal_title：Cancer

authors： Hsieh RW,Go RS,Abeykoon JP,Kapoor P,Kumar SK,Gertz MA,Buadi FK,Leung N,Gonsalves WI,Kourelis TV,Warsame RM,Dispenzieri A,Lacy MQ,Kyle RA,Rajkumar SV,Paludo J

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:Childhood cancer survivors have been reported to be vulnerable to psychiatric morbidities and risky health behavior. Suicides, substance abuse, accidents, and violence as causes of death can be regarded as an extreme manifestation of risky health behavior. In the current study, the authors studied the risk o...

journal_title：Cancer

authors： Korhonen LM,Taskinen M,Rantanen M,Erdmann F,Winther JF,Bautz A,Feychting M,Mogensen H,Talbäck M,Malila N,Ryynänen H,Madanat-Harjuoja L

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:Recent preclinical explorations strongly support the tumorigenic potential of bile on laryngopharyngeal mucosa. Herein, the authors describe, in bile-related human hypopharyngeal squamous cell carcinoma (HSCC), NF-κB-related messenger RNA (mRNA) and microRNA (miRNA) oncogenic phenotypes similar to those prev...

journal_title：Cancer

authors： Sasaki CT,Doukas SG,Costa J,Vageli DP

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:National and international bodies acknowledge the benefit of exercise for people with cancer, yet limited accessibility to related programing remains. Given their involvement in managing the disease, cancer centers can play a central role in delivering exercise-oncology services. The authors developed and im...

journal_title：Cancer

authors： Santa Mina D,Au D,Auger LE,Alibhai SMH,Matthew AG,Sabiston CM,Oh P,Ritvo PG,Chang EB,Jones JM

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Achieving a pathologic complete response (pCR) with neoadjuvant chemotherapy (NAC) in patients with muscle-invasive bladder cancer (MIBC) has been associated with improved overall survival (OS). This study was aimed at evaluating the impact of pathologic downstaging (pDS; ie, a pT stage at least 1 stage lowe...

journal_title：Cancer

authors： Martini A,Jia R,Ferket BS,Waingankar N,Plimack ER,Crabb SJ,Harshman LC,Yu EY,Powles T,Rosenberg JE,Pal SK,Vaishampayan UN,Necchi A,Wiklund NP,Mehrazin R,Mazumdar M,Sfakianos JP,Galsky MD

更新日期：2019-09-15 00:00:00

abstract：BACKGROUND:Because the addition of nimotuzumab to chemoradiation in patients with locally advanced head and neck cancer improved outcomes in a phase 2 study, the authors conducted a phase 3 study to confirm these findings. METHODS:This open-label, investigator-initiated, phase 3, randomized trial was conducted from 20...

journal_title：Cancer

authors： Patil VM,Noronha V,Joshi A,Agarwal J,Ghosh-Laskar S,Budrukkar A,Murthy V,Gupta T,Mahimkar M,Juvekar S,Arya S,Mahajan A,Agarwal A,Purandare N,Rangarajan V,Balaji A,Chaudhari SV,Banavali S,Kannan S,Bhattacharjee A,D

更新日期：2019-09-15 00:00:00

abstract：BACKGROUND:In the current study, the authors investigated the incidence of moderate to severe chemotherapy-induced peripheral neuropathy (CIPN) for chemotherapy regimens commonly used in current clinical practice for the treatment of patients with early breast cancer. Patient-reported and clinician-assessed CIPN severi...

journal_title：Cancer

authors： Nyrop KA,Deal AM,Reeder-Hayes KE,Shachar SS,Reeve BB,Basch E,Choi SK,Lee JT,Wood WA,Anders CK,Carey LA,Dees EC,Jolly TA,Kimmick GG,Karuturi MS,Reinbolt RE,Speca JC,Muss HB

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated an association between a diagnosis of cancer and the risk of suicide; however, they failed to account for psychiatric care before a cancer diagnosis, which may confound this relationship. The objective of this study was to assess the effect of a cancer diagnosis on the risk...

journal_title：Cancer

authors： Klaassen Z,Wallis CJD,Chandrasekar T,Goldberg H,Sayyid RK,Williams SB,Moses KA,Terris MK,Nam RK,Urbach D,Austin PC,Kurdyak P,Kulkarni GS

更新日期：2019-08-15 00:00:00

abstract：BACKGROUND:The benefits of an active lifestyle after a breast cancer diagnosis are well recognized, but the majority of survivors are insufficiently active. The ACTIVATE Trial examined the efficacy of an intervention (use of the Garmin Vivofit 2 activity monitor coupled with a behavioral feedback and goal-setting sessi...

journal_title：Cancer

authors： Lynch BM,Nguyen NH,Moore MM,Reeves MM,Rosenberg DE,Boyle T,Vallance JK,Milton S,Friedenreich CM,English DR

更新日期：2019-08-15 00:00:00

abstract：BACKGROUND:The optimal imaging for the staging of oropharyngeal cancer is not well defined. METHODS:The linked Surveillance, Epidemiology, and End Results (SEER)-Medicare database for 2006 through 2011 was used to compare patient characteristics and hospital region by the initial imaging modality used for patients wit...

journal_title：Cancer

authors： Morgan RL,Eguchi MM,Mueller AC,Daugherty SL,Amini A,Karam SD

更新日期：2019-08-15 00:00:00

abstract：BACKGROUND:Testing for oral high-risk human papillomavirus (HPV) DNA may be useful for identifying individuals at increased risk for HPV-driven oropharyngeal cancer (OPC). However, positivity for HPV DNA provides no information on the transforming potential of the infection. In contrast, the detection of high-risk HPV ...

journal_title：Cancer

authors： Rollo F,Pichi B,Benevolo M,Giuliani M,Latini A,Lorenzon L,Colafigli M,Frasca M,Pellini R,Cristaudo A,Donà MG

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Effective multidisciplinary rehabilitation programs supporting the return to work have become increasingly relevant for cancer survivors. In Germany, inpatient work-related medical rehabilitation programs consider treatment modules of work-related diagnostics, work-related functional capacity training, psych...

journal_title：Cancer

authors： Fauser D,Wienert J,Beinert T,Schmielau J,Biester I,Krüger HU,Presl A,Bethge M

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Commonly used chemotherapies can be toxic to the ovaries. To the authors' knowledge, the majority of studies evaluating receipt of fertility counseling for women in their reproductive years have been performed in specific settings, thereby limiting generalizability. METHODS:A nationwide sample of US women d...

journal_title：Cancer

authors： Hawkins Bressler L,Mersereau JE,Anderson C,Rodriguez JL,Hodgson ME,Weinberg CR,Sandler DP,Nichols HB

更新日期：2019-08-01 00:00:00

abstract：:Meaning and purpose in life are associated with the mental and physical health of patients with cancer and survivors and also constitute highly valued outcomes in themselves. Because meaning and purpose are often threatened by a cancer diagnosis and treatment, interventions have been developed to promote meaning and p...

journal_title：Cancer

authors： Park CL,Pustejovsky JE,Trevino K,Sherman AC,Esposito C,Berendsen M,Salsman JM

更新日期：2019-07-15 00:00:00

abstract：BACKGROUND:The current randomized, controlled, multicenter clinical trial was conducted to investigate the efficacy of concurrent neoadjuvant chemotherapy (NCT) and estrogen deprivation in patients with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer. METHODS:Eli...

journal_title：Cancer

authors： Yu KD,Wu SY,Liu GY,Wu J,Di GH,Hu Z,Hou YF,Chen CM,Fan L,Tang LC,Shen ZZ,Wu KJ,Zhuang ZG,Zhang HW,Shao ZM

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Although cancer has become one of the leading health burdens, to the authors' knowledge, evidence regarding its relationship with a healthy lifestyle in the Chinese population remains limited. METHODS:The authors evaluated the association between clustering of healthy lifestyle factors and cancer risk using...

journal_title：Cancer

authors： Wang X,Yang X,Li J,Liu F,Chen J,Liu X,Cao J,Shen C,Yu L,Lu F,Wu X,Zhao L,Wu X,Li Y,Hu D,Huang J,Lu X,Gu D

更新日期：2019-06-15 00:00:00